Rx Direct & Cost Savings Card | TRIBENZOR® - Tribenzor

The Pre-activated Savings Card

For patients with commercial insurance— eligible patients may pay as little as $5 per month with the Pre-activated Savings Card^*

Bring your Pre-activated Savings Card to a retail pharmacy with your prescription
You can use your previous Pre-Activated Savings or Savings That Last card to obtain the $5 per month benefit. You do not need to download the new card to receive this offer

^*See below for Eligibility Criteria and Terms & Conditions.

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*Savings Card Offer: Eligibility Criteria and Terms & Conditions

Eligibility Criteria: Resident of US or Puerto Rico with valid prescription for product listed on front of the Savings Card. Not valid if enrolled in state or federally funded prescription benefit program (eg, Medicare Part D/Medicaid) or if prohibited by law.

Terms & Conditions: For patients with commercial insurance, savings benefits for these products do not cover insurance deductibles and apply after the $5 out-of-pocket expense is met for each 30-day prescription fill or $15 for 90-day prescription fill. Savings are subject to a maximum benefit. Patients without insurance receive $25 off the retail price for each prescription fill. Offer not valid with any other program, discount or incentive. For California and Massachusetts residents, the Co-pay Card is not valid for BENICAR, BENICAR HCT, AZOR, or TRIBENZOR that has an AB-rated generic equivalent as determined by the United States Food and Drug Administration. Patient is not eligible if prescriptions are paid in part or full by any state or federally funded programs, including but not limited to Medicare or Medicaid, Medigap, VA, DOD or TriCare and where prohibited by law. It is illegal for any person to sell, purchase, or trade or to counterfeit the Savings Card. This is not insurance. This card carries no cash value. Valid for up to a 365-day supply per calendar year. By using the Savings Card, patients certify they meet the Eligibility Criteria and Terms & Conditions.

Pharmacist & Patient Questions: Call 1-877-264-2440 (8 AM–8 PM ET, M–F)

Pharmacist Conditions: By using this offer, you certify that the Eligibility Criteria are met. Submit transaction to McKesson Corp, using BIN #610524. If primary coverage exists, input offer information as secondary coverage and transmit using COB segment of NCPDP transaction. Applicable discounts will be displayed in the transaction response. Acceptance of this offer is subject to LoyaltyScript^® program Terms and Conditions posted at www.mckesson.com/mprstnc.

McKesson Corporation–Scottsdale, AZ 85251–Patent Pending

Cosette Pharmaceuticals, Inc., reserves the right to rescind, revoke, or amend this program, at any time, without notice.

Trademarks not owned by Cosette Pharmaceuticals, Inc., are property of their respective owners.

Important Safety Information

INDICATIONS

BENICAR, BENICAR HCT, AZOR, and TRIBENZOR are prescription medicines used to lower high blood pressure (hypertension) in adults. BENICAR may be used in pediatric patients six years of age or older to lower high blood pressure. Medicines that lower blood pressure lower the chance of having a stroke or heart attack. The safety and effectiveness of BENICAR HCT, AZOR, and TRIBENZOR in pediatric patients have not been established.

Patients may require more than one type of blood pressure lowering medication. Along with lowering blood pressure, a complete treatment plan to lower the chance of a stroke or heart attack may include exercise, a diet low in sodium, stopping smoking, controlling cholesterol, treatment or prevention of blood clots, and controlling blood sugar.

BENICAR, BENICAR HCT, AZOR, and TRIBENZOR may be used alone or with other medicines to treat high blood pressure.

AZOR may be used as the first medicine to treat high blood pressure in people who are likely to need more than 1 blood pressure medicine to reach their blood pressure goals.

AZOR is not for use as the first medicine to treat high blood pressure for people who are 75 years of age and older or have liver problems.

BENICAR HCT and TRIBENZOR are not for use as the first medicine to treat high blood pressure.

Important Safety Information for BENICAR^®, BENICAR HCT^®, AZOR^®, and TRIBENZOR^®

WARNING: DO NOT TAKE BENICAR, BENICAR HCT, AZOR, OR TRIBENZOR DURING PREGNANCY

BENICAR, BENICAR HCT, AZOR, and TRIBENZOR can cause harm or death to an unborn baby
Talk with your doctor about other ways to lower your blood pressure if you become pregnant
If you get pregnant while taking BENICAR, BENICAR HCT, AZOR, or TRIBENZOR, tell your doctor immediately

Please see the WARNINGS AND PRECAUTIONS section of the Full Product Information about Fetal Toxicity.

Do not take BENICAR, BENICAR HCT, AZOR, or TRIBENZOR if you:

Take medicine that contains aliskiren and you have diabetes or kidney problems

Do not take BENICAR HCT or TRIBENZOR if you:

Have less urine than normal or if you cannot urinate
Are allergic to any component of this medicine
Are allergic to other sulfonamide type medicines
Have not taken any other medicines to treat your high blood pressure before

Children that are less than 1 year of age must not receive BENICAR for high blood pressure. Children of any age should not receive AZOR, BENICAR HCT, or TRIBENZOR.

Before taking BENICAR, BENICAR HCT, AZOR, or TRIBENZOR, tell your doctor if you are pregnant or plan to become pregnant as soon as possible. Also tell your doctor if you are breast-feeding or plan to breast-feed. A medicine in BENICAR HCT and TRIBENZOR can pass into your breast milk. This may harm your baby. You and your doctor should decide if you will take BENICAR, BENICAR HCT, AZOR, or TRIBENZOR or breast-feed. You should not do both. (Please see Boxed WARNING regarding Fetal Toxicity).

Let your doctor know about any health conditions you may have
Tell your doctor if you are allergic to any of the ingredients in BENICAR, BENICAR HCT, AZOR, or TRIBENZOR (see Full Product Information for a list of the ingredients in BENICAR, BENICAR HCT, AZOR, or TRIBENZOR, as applicable). Also let your doctor know if you have any of the health conditions listed below:

Before you take these medicines:	Let your doctor know if you have these, or any other, medical conditions:
BENICAR	Kidney problems A lot of diarrhea or are vomiting Diabetes
BENICAR HCT	Kidney or liver problems Lupus A lot of diarrhea or are vomiting History of allergy or bronchial asthma Diabetes Gout
AZOR	Kidney or liver problems Heart problems (including coronary heart disease and narrowing of the aortic valve) A lot of diarrhea or are vomiting Diabetes
TRIBENZOR	Kidney or liver problems Lupus Heart problems (including coronary heart disease and narrowing of the aortic valve) A lot of diarrhea or are vomiting History of allergy or bronchial asthma Diabetes Gout

Tell your doctor about all the medicines you take

Some of your other medicines and BENICAR, BENICAR HCT, AZOR, or TRIBENZOR could affect each other. This may cause serious side effects.

These medicines may include prescription and nonprescription medicines, vitamins, and herbal supplements:

If you take BENICAR, tell your doctor if you also take:	If you take AZOR, tell your doctor if you also take:
Water pills (diuretics) Other medicines for high blood pressure or a heart problem Potassium supplements or a salt substitute that contains potassium Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) Welchol^® (colesevelam hydrochloride) Lithium for certain types of depression	Water pills (diuretics) Other medicines for high blood pressure or a heart problem Potassium supplements or a salt substitute that contains potassium Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) Welchol^® (colesevelam hydrochloride) Simvastatin, a cholesterol-lowering drug Lithium for certain types of depression CYP3A inhibitors and CYP3A inducers (medicines that affect the liver)
If you take BENICAR HCT, tell your doctor if you also take:	If you take TRIBENZOR, tell your doctor if you also take:
Water pills (diuretics) Other medicines for high blood pressure or a heart problem Potassium supplements or a salt substitute that contains potassium Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) Welchol^® (colesevelam hydrochloride) Diabetes medicine including insulin Lithium for certain types of depression Steroids Cholesterol-lowering medicines (e.g., cholestyramine, colestipol)	Water pills (diuretics) Other medicines for high blood pressure or a heart problem Potassium supplements or a salt substitute that contains potassium Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) Welchol^® (colesevelam hydrochloride) Diabetes medicine including insulin Narcotic pain medicine Sleeping pills and antiseizure medicines called barbiturates Lithium for certain types of depression Steroids Cholesterol-lowering medicines (including simvastatin) Cyclosporine or tacrolimus (medicines used to alter the way your immune system works) CYP3A inhibitors and CYP3A inducers (medicines that affect the liver)

About alcohol and other drug interactions

If you are taking TRIBENZOR do not drink alcohol. Your blood pressure may become too low if you drink alcohol.

Some of your other medicines and BENICAR, BENICAR HCT, AZOR, or TRIBENZOR could affect each other. This may cause serious side effects. Take BENICAR, BENICAR HCT, AZOR, or TRIBENZOR as prescribed by your doctor. Talk with your doctor before you stop taking BENICAR, BENICAR HCT, AZOR, or TRIBENZOR.

Know about possible side effects

For BENICAR, BENICAR HCT, AZOR, and TRIBENZOR

Serious side effects may include injury or death to an unborn baby; low blood pressure (hypotension), which may cause you to feel faint or dizzy; and kidney problems, which may get worse in people with kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose. Tell your doctor if you get swelling in your feet, ankles, or hands, or have unexplained weight gain. These may be signs of kidney problems. If you have heart failure, your doctor should also check your kidney function before prescribing these medicines. Tell your doctor if you are experiencing these symptoms.

Serious side effects may also include severe, chronic diarrhea with considerable weight loss, which may develop months to years after starting BENICAR, BENICAR HCT, AZOR, or TRIBENZOR. Tell your doctor if you are experiencing these symptoms.

Additional side effects for BENICAR and BENICAR HCT only

Because of the thiazide diuretic (water pill), an ingredient in BENICAR HCT, other serious side effects may include allergic reactions and changes in body salts (such as sodium and potassium) and fluids. Tell your doctor if you have these signs and symptoms: dry mouth, thirst, weakness, tiredness or sleepiness, restlessness, confusion, seizures, muscle pains or cramps, muscle tiredness, dizziness or fainting, having little or no urine output, or nausea and vomiting.

The thiazide diuretic in BENICAR HCT can also cause eye problems, which may lead to vision loss. Symptoms can happen within hours to weeks of starting BENICAR HCT. Tell your doctor if you have a decrease in vision or eye pain.

The most common side effect of BENICAR and BENICAR HCT was dizziness. Other side effects of BENICAR HCT included upper respiratory tract infections, more uric acid in the blood, and nausea.

Do not take BENICAR HCT as your first medicine for the treatment of your high blood pressure.

Additional side effects for AZOR only

Because of amlodipine, an ingredient in AZOR, other serious side effects may include worsening chest pain or heart attack. Get medical help right away if you have chest pain that gets worse or does not go away.

The most common side effect of AZOR was swelling from fluid buildup in the body. Other less common side effects were blood pressure that is too low; blood pressure that becomes too low after standing up too quickly; rash; itching; pounding or racing heartbeat; more frequent urination; and excessive urination at night. Other side effects may include headache, dizziness, and redness of the face and neck (flushing).

Do not take AZOR as your first medicine for the treatment of your high blood pressure if you have liver problems or if you are 75 years of age and older.

Additional side effects for TRIBENZOR only

Because of amlodipine, an ingredient in TRIBENZOR, other serious side effects may include chest pain that gets worse or heart attack. Get medical help right away if you have chest pain that gets worse or does not go away. TRIBENZOR also contains a thiazide diuretic (water pill), which may cause allergic reactions and changes in body salts (such as sodium and potassium) and fluids. Tell your doctor if you have signs of a change in body salts and body fluids. Signs of a change include: dry mouth, thirst, weakness, tiredness or sleepiness, or restlessness. These signs may also include confusion, seizures, muscle pains or cramps, muscle tiredness, dizziness or fainting, having little or no urine, fast heartbeat, and nausea and vomiting.

The thiazide diuretic in TRIBENZOR can also cause eye problems which may lead to vision loss. Symptoms can happen within hours to weeks of starting TRIBENZOR. Tell your doctor right away if you have a decrease in vision or eye pain.

The most common side effects of TRIBENZOR include dizziness; swelling of the ankles, feet, and hands; headache; tiredness; stuffy or runny nose and sore throat; muscle twitching (spasms); nausea; upper respiratory tract infection; diarrhea; urinary tract infection; and swelling of the joints.

Do not take TRIBENZOR as your first medicine for the treatment of your high blood pressure.

Tell your doctor if you have any side effect that bothers you or does not go away. Not all the possible side effects of BENICAR, BENICAR HCT, AZOR, or TRIBENZOR have been mentioned in the Important Safety Information. For more information, talk with your doctor or pharmacist. Call your doctor for medical advice about side effects.

To report side effects, contact Cosette Pharmaceuticals, Inc., at 1-800-922-1038 or the FDA at 1-800-332-1088 or www.fda.gov/medwatch.

Please see Full Prescribing Information for BENICAR, BENICAR HCT, AZOR, and TRIBENZOR

Take advantage of saving

on your prescription

WARNING: DO NOT TAKE BENICAR, BENICAR HCT, AZOR, OR TRIBENZOR DURING PREGNANCY

Please see the WARNINGS AND PRECAUTIONS section of the Full Product Information about Fetal Toxicity.